Which of the following can negatively affect driving ability?

The choice that encompasses illegal drugs, prescription drugs, and over-the-counter drugs is correct because all of these substances can significantly impair driving ability.

Illegal drugs are well-known for their potential to compromise cognitive and motor functions, significantly increasing the risk of accidents. However, it's important to recognize that prescription drugs can also pose similar risks. Many medications, even those that are legally prescribed, can have side effects such as drowsiness, dizziness, or impaired judgment, which can make driving hazardous. For instance, medications for pain, anxiety, or sleep disorders often carry warnings about their effects on driving.

Over-the-counter drugs, too, can impact driving abilities. Common medications, such as antihistamines or cold and flu remedies, can lead to drowsiness and reduced alertness, potentially endangering the driver and others on the road.

Thus, it is critical for drivers to be aware of their medications—both prescription and over-the-counter—as well as any illegal substances, and to understand how these can adversely affect their ability to drive safely. This comprehensive view supports safer driving practices and emphasizes the importance of being informed about all substances that a driver may consume.